MULTIPLE ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA OF THE HAND - REPORT OF A CASE AND REVIEW OF THE LITERATURE

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare angioprol iferative disorder with a predilection for the head and neck region, A LHE is very rare in the extremities and even more rare in the hand, wi th only single cases reported in this location, We describe the occurr ence of multiple lesions of ALHE on the right hand of a 26-year-old wo man, We report this unusual occurrence and convey a clinical different ial diagnosis with other benign and malignant conditions of the hand, All the lesions of the palm were excised out as a unit, the subungual lesion removed completely, and the involved segment of the right commo n digital artery excised, The tissues were processed for routine histo logic examination as well as for histochemical and immunohistochemical tests, Electron microscopic study was also performed, Recurrent lesio ns on the same hand were also excised, Histologic examination of all t he lesions revealed classic morphologic features of ALHE, The results of special studies confirmed the endothelial nature of the proliferati ng cells, ALHE can present as multiple lesions in the hand, and can ar ise in a subungual location, The possibility of larger arteries being involved should be considered, Recurrent lesions may appear months aft er the original presentation.