INHIBITION OF NARINGINASE (L-RHAMNOSIDASE) BY PIPERIDINE ANALOGS OF L-RHAMNOSE - SCAFFOLDS FOR LIBRARIES INCORPORATING TRIHYDROXYPIPECOLIC ACIDS

Authors
SHILVOCK JP WHEATLEY JR DAVIS B NASH RJ GRIFFITHS RC JONES MG MULLER M CROOK S WATKIN DJ SMITH C BESRA GS BRENNAN PJ FLEET GWJ
Citation
Jp. Shilvock et al., INHIBITION OF NARINGINASE (L-RHAMNOSIDASE) BY PIPERIDINE ANALOGS OF L-RHAMNOSE - SCAFFOLDS FOR LIBRARIES INCORPORATING TRIHYDROXYPIPECOLIC ACIDS, Tetrahedron letters, 37(47), 1996, pp. 8569-8572
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
47
Year of publication
1996
Pages
8569 - 8572
Database
ISI
SICI code
0040-4039(1996)37:47<8569:ION(BP>2.0.ZU;2-E
Abstract
L-Deoxyrhamnojirimycin 1 does not inhibit naringinase significantly bu t 5-epi-L-deoxyrhamnojirimycin 2 is a potent inhibitor. Conversely, al pha-C-glycosides of 1 are good inhibitors of L-rhamnosidase whereas th ose of 2 are not. Intermediate azabicyclic lactones are Likely to be o f use for the: incorporation of a number of trihydroxypipecolic acids into peptide libraries. Copyright (C) 1996 Elsevier Science Ltd