We study the restrictions imposed by cancellation of the tadpoles for
two-, three-, and four-form gauge fields in string theory, hi-theory a
nd F-theory compactified to two, three and four dimensions, respective
ly, For a large class of supersymmetric vacua, turning on a sufficient
number of strings, membranes and three-branes, respectively, can canc
el the tadpoles, and preserve supersymmetry, However, there are cases
where the tadpole cannot be removed in this way, either because the ta
dpole is fractional, or because of its sign. For M-theory and F-theory
compactifications, we also explore the relation of the membranes and
three-branes to the non-perturbative space-time superpotential.