THROMBIN RECEPTOR EXPRESSION IN RHEUMATOID AND OSTEOARTHRITIC SYNOVIAL TISSUE

Citation
R. Morris et al., THROMBIN RECEPTOR EXPRESSION IN RHEUMATOID AND OSTEOARTHRITIC SYNOVIAL TISSUE, Annals of the Rheumatic Diseases, 55(11), 1996, pp. 841-843
Citations number
17
Categorie Soggetti
Rheumatology
ISSN journal
00034967
Volume
55
Issue
11
Year of publication
1996
Pages
841 - 843
Database
ISI
SICI code
0003-4967(1996)55:11<841:TREIRA>2.0.ZU;2-C
Abstract
Objective-To investigate the possibility that synovial cells might res pond to thrombin in the inflamed human joint, using immunohistochemica l detection of thrombin receptors. Methods-Frozen sections of synovial membrane from 20 patients with rheumatoid arthritis, 16 with osteoart hritis, and four normal controls were stained using a monoclonal antib ody to the human thrombin receptor. Sections were also double stained for both receptors and non-specific esterase. Results-Receptor positiv e cells were present in rheumatoid synovia, with some cells also stain ing positively for nonspecific esterase. In contrast, both osteoarthri tic and normal synovia contained very few cells expressing receptors. Conclusions-Thrombin may mediate important pathological changes during chronic inflammatory joint disease.