APOLIPOPROTEIN-AI-CIII, APOLIPOPROTEIN-B AND APOLIPOPROTEIN-CII GENE POLYMORPHISMS IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS- ASSOCIATION WITH HYPERLIPIDEMIA
C. Gutierrez et al., APOLIPOPROTEIN-AI-CIII, APOLIPOPROTEIN-B AND APOLIPOPROTEIN-CII GENE POLYMORPHISMS IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS- ASSOCIATION WITH HYPERLIPIDEMIA, Medicina Clinica, 107(15), 1996, pp. 561-565
BACKGROUND: Dislipidaemia is an usual feature in patients affected by
non insulin dependent diabetes mellitus, Several studies show that thi
s disease could be genetically determined. The aim of this study was t
o ascertain whether any of the genetic polymorphism remaining in three
apolipoprotein loci (apolipoprotein AI-CIII, B100 and CII) is related
with the presence of dislipidaemia in non insulin dependent diabetes
mellitus patients. PATIENTS AND METHODS: 53 non insulin dependent diab
etes mellitus patients with less than 5 years evolution and treated on
ly with diet, were included. 86 healthy persons were included as the c
ontrol group, The lipidic parameters analyzed were: cholesterol, LDL c
holesterol, HDL cholesterol, triglycerides, apolipoprotein Al, B and l
ipoprotein (a). The following polymorphic variants were analyzed: RFLP
-Sacl of the apolipoprotein AI-CIII-AIV cluster, RFLP-Xbal of the apol
ipoprotein B100 region and the RFLP-Taql of the apolipoprotein E-CI-CI
I cluster. RESULTS: There were no genetic nor allelic differences in t
he distribution of the genes, between controls acid diabetic patients,
Regarding the apolipoprotein CII gen, the diabetic patients with the
T2T2 genotype had higher triglyceride levels (p < 0.01) compared with
the remaining genotypes and compared with the control group having the
same genotype (p < 0.01) matched for sex, age and body mass index. Th
ere was no difference in the metabolic parameters' distribution relate
d to the genotypic distribution of the apolipoproteins AI-CIII and B10
0 genes. CONCLUSIONS: The apolipoprotein CII can be related with the p
resence of hypertriglyceridaemia in non insulin dependent diabetes mel
litus patients.