ASSOCIATE RISK-FACTORS TO THE PREVALENCE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS IN LEJONA (VIZCAYA, SPAIN)

BACKGROUND: The aim of study was to define risk factors (age, body mas s index, height, weight, systolic and dyastolic blood pressure) associ ated to non insulin dependent diabetes mellitus (NIDDM) and abnormal g lucose tolerance (AGT). PATIENTS, MATERIAL AND METHODS: This study was carried out in people greater than or equal to 30 years old in Lejona (Vizcaya) by randomized sampling of population, stratified by pyramid s of age and sex (N = 862), with a low rate of non-responders (12.6%), An oral glucose tolerance test was done following the criteria recomm ended by the Committee of Experts of the World Health Organization (WH O), A multivariate analysis was performed, with presence/absence of NI DDM and/or AGT, as dependent variable in several models of logistic re gression. RESULTS: The prevalence of NIDDM was 6.4% (56% previously un known), Strong association of NIDDM with age, BMI, and systolic blood pressure (SBP) was observed both in univariate, as well as multivariat e analysis. However, SBP lost its value in the multivariate study, Mul tivariate analysis showed that NIDDM was 8.2 fold more frequent in the population greater than or equal to 60 years than in the less than or equal to 45 years old group, NIDDM was 8.3 fold more frequent when BM I greater than or equal to 30 kg/m(2) compared to less than or equal t o 25, NIDDM was 3.8 fold more frequent in the population with SBP grea ter than or equal to 140 mmHg than in the group with SBP less than or equal to 120 mmHg, The prevalence of AGT in women is almost double tha n in men (13.4% vs 7.3%), Risk factors were also associated with AGT. CONCLUSIONS: Weight and SBP are important risk factors for NIDDM and A GT prediction, The possibility of modifying these factors could possib ly allow interventions in order to decrease the prevalence of NIDDM an d AGT.