SYNTHESIS DESIGN OF THE NEW AJMALINE DERIVATIVE BY MEANS OF MATHEMATICAL-MODELING

Authors
SERGEEVA H MININA S KORBELAINEN E POZHARITSKAYA O
Citation
H. Sergeeva et al., SYNTHESIS DESIGN OF THE NEW AJMALINE DERIVATIVE BY MEANS OF MATHEMATICAL-MODELING, Hungarian journal of industrial chemistry, 24(4), 1996, pp. 291-293
Citations number
8
Categorie Soggetti
Engineering, Chemical",Chemistry
Journal title
Hungarian journal of industrial chemistry → ACNP
ISSN journal
01330276
Volume
24
Issue
4
Year of publication
1996
Pages
291 - 293
Database
ISI
SICI code
0133-0276(1996)24:4<291:SDOTNA>2.0.ZU;2-O
Abstract
The new ajmaline derivative possessing high antiarrhythmic activity wa s synthesised on the basis of alkaloid isolated from the raw material by means of biotechnological method. The mathematical modelling of the alkylation process was carried out by means of polyfactor regression analysis for the choice of synthesis conditions. It is known, that the alkaloid ajmaline, isolated from biomass of culture tissue of Rauwolf ia, can serve as the basis for the development of highly effective ant iarrhythmic drugs [1].