PRODUCTION OF HUMAN TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-6, AND INTERLEUKIN-10 IS INDUCED BY LACTIC-ACID BACTERIA

Authors
MIETTINEN M VUOPIOVARKILA J VARKILA K
Citation
M. Miettinen et al., PRODUCTION OF HUMAN TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-6, AND INTERLEUKIN-10 IS INDUCED BY LACTIC-ACID BACTERIA, Infection and immunity, 64(12), 1996, pp. 5403-5405
Citations number
32
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
12
Year of publication
1996
Pages
5403 - 5405
Database
ISI
SICI code
0019-9567(1996)64:12<5403:POHTIA>2.0.ZU;2-U
Abstract
To investigate the role of cytokines in interactions between lactic ac id bacteria and the immune system, we measured production of tumor nec rosis factor alpha, interleukin-6 (IL-6), and IL-10 from human periphe ral blood mononuclear cells after stimulation with live or glutaraldeh yde-fixed bacteria. Production of tumor necrosis factor alpha, IL-6, a nd, in some cases, IL-10 was induced in amounts even greater than thos e obtained with lipopolysaccharide as a stimulant. Our results suggest that lactic acid bacteria can stimulate nonspecific immunity.