RECOGNITION OF IMMUNOGLOBULIN A1 BY ORAL ACTINOMYCES AND STREPTOCOCCAL LECTINS

Authors
RUHL S SANDBERG AL COLE MF CISAR JO
Citation
S. Ruhl et al., RECOGNITION OF IMMUNOGLOBULIN A1 BY ORAL ACTINOMYCES AND STREPTOCOCCAL LECTINS, Infection and immunity, 64(12), 1996, pp. 5421-5424
Citations number
42
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
12
Year of publication
1996
Pages
5421 - 5424
Database
ISI
SICI code
0019-9567(1996)64:12<5421:ROIABO>2.0.ZU;2-8
Abstract
Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GaINAc- and sialic acid-reactive lectins, respectively, we re adherent to immobilized secretory immunoglobulin A (IgA) and two Ig A1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.