EFFECTS OF SAND FLY VECTOR SALIVA ON DEVELOPMENT OF CUTANEOUS LESIONSAND THE IMMUNE-RESPONSE TO LEISHMANIA-BRAZILIENSIS IN BALB C MICE/

Authors
LIMA HC TITUS RG
Citation
Hc. Lima et Rg. Titus, EFFECTS OF SAND FLY VECTOR SALIVA ON DEVELOPMENT OF CUTANEOUS LESIONSAND THE IMMUNE-RESPONSE TO LEISHMANIA-BRAZILIENSIS IN BALB C MICE/, Infection and immunity, 64(12), 1996, pp. 5442-5445
Citations number
36
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
12
Year of publication
1996
Pages
5442 - 5445
Database
ISI
SICI code
0019-9567(1996)64:12<5442:EOSFVS>2.0.ZU;2-V
Abstract
The saliva of the sand fly vector of leishmaniasis significantly enhan ced infection with doses of >10(4) Leishmania braziliensis parasites i n BALB/c mice. With a dose of 10(7) L. braziliensis parasites, 60 to 7 0% of the mice developed lifetime infections. Mice infected with L. br aziliensis plus saliva produced two- to threefold more interleukin-4 t han did mice infected with L. braziliensis alone. Treatment with a neu tralizing anti-interleukin-4 antibody abrogated the effects of the sal iva.