SHORT-TERM CANINE IMPLANTATION OF A GLUCOSE MONITORING-TELEMETRY DEVICE

Citation
P. Atanasov et al., SHORT-TERM CANINE IMPLANTATION OF A GLUCOSE MONITORING-TELEMETRY DEVICE, Medical engineering & physics, 18(8), 1996, pp. 632-640
Citations number
36
Categorie Soggetti
Engineering, Biomedical
ISSN journal
13504533
Volume
18
Issue
8
Year of publication
1996
Pages
632 - 640
Database
ISI
SICI code
1350-4533(1996)18:8<632:SCIOAG>2.0.ZU;2-E
Abstract
In this study we report the development and short-term in vivo evaluat ion of an integrated implantable device consisting of an amperometric glucose biosensor, a miniature potentiostat, a FM signal transmitter, and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was impl anted under the skin of medium-size anaesthetized dog. The experimenta l set-up included several methods for data collection: analog recordin g via wired X-T chart recorders; data collection by wearable microproc essor-data logger, and remote data collection via antenna and receiver linked to a computer-based data acquisition system. The device (senso r) performance was evaluated in vitro prior to implantation, using dif ferent model solutions simulating the physiological environment. A lin ear response to glucose concentration was obtained up to 25 mM glucose , with a sensitivity of 0.5 mu A/mM. The results of short-term subcuta neous implantation of the integrated device reveal adequate monitoring of an artificially-induced glycaemia. The delay-time was 3-7 minutes. These tests demonstrate the feasibility of data transmission to the t elemetry system through the skin of a medium-sized dog and allow the c ommencement of chronic in vivo experimentation. Copyright (C) 1996 Els evier Science Ltd for IPEMB.