In this study we report the development and short-term in vivo evaluat
ion of an integrated implantable device consisting of an amperometric
glucose biosensor, a miniature potentiostat, a FM signal transmitter,
and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was impl
anted under the skin of medium-size anaesthetized dog. The experimenta
l set-up included several methods for data collection: analog recordin
g via wired X-T chart recorders; data collection by wearable microproc
essor-data logger, and remote data collection via antenna and receiver
linked to a computer-based data acquisition system. The device (senso
r) performance was evaluated in vitro prior to implantation, using dif
ferent model solutions simulating the physiological environment. A lin
ear response to glucose concentration was obtained up to 25 mM glucose
, with a sensitivity of 0.5 mu A/mM. The results of short-term subcuta
neous implantation of the integrated device reveal adequate monitoring
of an artificially-induced glycaemia. The delay-time was 3-7 minutes.
These tests demonstrate the feasibility of data transmission to the t
elemetry system through the skin of a medium-sized dog and allow the c
ommencement of chronic in vivo experimentation. Copyright (C) 1996 Els
evier Science Ltd for IPEMB.