BINDING OF HEPARAN-SULFATE TO FIBROBLAST GROWTH FACTOR-II - TOTAL SYNTHESIS OF A PUTATIVE PENTASACCHARIDE BINDING-SITE

Authors
KOVENSKY J DUCHAUSSOY P PETITOU M SINAY P
Citation
J. Kovensky et al., BINDING OF HEPARAN-SULFATE TO FIBROBLAST GROWTH FACTOR-II - TOTAL SYNTHESIS OF A PUTATIVE PENTASACCHARIDE BINDING-SITE, Tetrahedron : asymmetry, 7(11), 1996, pp. 3119-3128
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
11
Year of publication
1996
Pages
3119 - 3128
Database
ISI
SICI code
0957-4166(1996)7:11<3119:BOHTFG>2.0.ZU;2-8
Abstract
The total chemical synthesis of the pentasaccharide methyl O-(alpha-L- idopyranosyluronic ulfamido-alpha-D-glucopyranosyl)-(1-->4)-O-(alpha- L-idopyranosyluronic osyl)-(1-->4)-2-O-sulfo-alpha-L-idopyranosiduroni c acid is reported. This sequence is a possible candidate for binding to basic fibroblast growth factor (FGF-2) (J. Biol. Chem., 1993, 268, 23898-23905). Copyright (C) 1996 Published by Elsevier Science Ltd