AMPLIFICATION OF FARNESYL-PROTEIN TRANSFERASE INHIBITORY ACTIVITY FROM ASPERGILLUS-FUMIGATUS F93 PLACKETT-BURMAN DESIGN

Authors
SON KH KIM YK LEE HW LEE WS KIM SU JEONG TS KWON BM BOK SH
Citation
Kh. Son et al., AMPLIFICATION OF FARNESYL-PROTEIN TRANSFERASE INHIBITORY ACTIVITY FROM ASPERGILLUS-FUMIGATUS F93 PLACKETT-BURMAN DESIGN, Biotechnology letters, 18(11), 1996, pp. 1297-1300
Citations number
8
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
18
Issue
11
Year of publication
1996
Pages
1297 - 1300
Database
ISI
SICI code
0141-5492(1996)18:11<1297:AOFTIA>2.0.ZU;2-Y
Abstract
Fermentation optimization for the fungus Aspergillus fumigatus F93 was performed to amplify the most promising biological activity. Twelve a ctive variables were analysed and optimized by the Plackett-Burman des ign, consisting of 16 experiments. Farnesyl protein transferase inhibi tory activity showed the best response for the design, and selected pa rameters were confirmed by separate experiments in the optimized ferme ntation condition.