CYTOMEGALOVIRUS GB GENOTYPE DISTRIBUTION DIFFERS IN HUMAN-IMMUNODEFICIENCY-VIRUS - INFECTED PATIENTS AND IMMUNOCOMPROMISED ALLOGRAFT RECIPIENTS

Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes, gB genotypes were studied in patients infected with human immunodefici ency virus (HIV) and in allograft transplantation recipients. In allog raft recipients, the distribution of gB1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with < 100/m u L CD4 cells, gB1 was found significantly less often than in allograf t recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gB1 and increased incidence of gB2 c ompared with allograft recipients was also seen in urine of HIV-infect ed patients and reflected the distribution seen in leukocytes, gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/mu L CD4 cells, gB1-4 genotypes we re similar in patients with < 100/mu L CD4 cells with or without retin itis.