S. Gilman et al., EFFECTS OF DISULFIRAM ON POSITRON EMISSION TOMOGRAPHY AND NEUROPSYCHOLOGICAL STUDIES IN SEVERE CHRONIC-ALCOHOLISM, Alcoholism, clinical and experimental research, 20(8), 1996, pp. 1456-1461
Disulfiram is an aldehyde dehydrogenase inhibitor that is widely used
as an adjunctive agent in the treatment of patients with severe chroni
c alcoholism. Recent positron emission tomography (PET) studies of loc
al cerebral metabolic rates for glucose (ICMRglc) and benzodiazepine r
eceptor binding in alcoholic patients have shown regional cerebral abn
ormalities; however, some of the patients were studied while receiving
disulfiram, which could influence the biochemical processes under inv
estigation, In a retrospective investigation, we examined the influenc
e of disulfiram administration on the results of PET studies of ICMRgl
c and benzodiazepine receptor binding and neuropsychological tests of
cognition and executive function in patients with severe chronic alcoh
olism. [F-18]Fluorodeoxyglucose was used to measure ICMRglc in 48 male
patients, including 11 receiving and 37 not receiving disulfiram in t
herapeutic doses, [C-11]Flumazenil was used to measure benzodiazepine
receptor binding in 17 male patients, including 3 receiving and 14 not
receiving disulfiram. All patients studied with FMZ were also examine
d with fluorodeoxyglucose, PET studies of ICMRglc revealed significant
ly decreased global values in the patients receiving disulfiram compar
ed with those not receiving disulfiram. PET studies of benzodiazepine
receptor binding revealed decreased flumazenil influx and distribution
volume in patients receiving disulfiram. The neuropsychological tests
demonstrated no differences between the two groups of subjects, The f
indings suggest that disulfiram may influence the results of PET studi
es of glucose metabolism and benzodiazepine receptor binding.