MULTIPLE-DOSE PHARMACOKINETICS OF CEFPIROME IN LONG-TERM HEMODIALYSISWITH HIGH-FLUX MEMBRANES

Cefpirome is a cephalosporin eliminated primarily by kidneys that requ ires dosage reduction in patients with renal failure. The pharmacokine tic parameters were studied in 10 patients with end-stage renal diseas e who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12. 2 +/- 5.4 mu g/ml and peak serum concentrations of 99.6 +/- 82.1 mu g/ ml. After 31/2 hours of hemodialysis with polysulfone high-flux membra nes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half- life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.