Among 136 adults with mental illness and mental retardation who were c
onsecutively treated at a development disabilities clinic, 25 reported
that they currently smoked cigarettes. Among those with mild and bord
erline retardation, smoking rates were 30 and 37 percent, respectively
. Smokers were significantly more likely than nonsmokers to drink alco
hol, use other drugs, and be sexually active. Multiple regression anal
ysis found that a mild or borderline level of retardation and a diagno
sis of schizophrenia were significant predictors of smoking. Mentally
retarded persons with mental illness are at risk of tobacco-related di
sease and may benefit from prevention and smoking cessation interventi
ons.