HUMAN NATURAL-KILLER-CELL RECEPTORS INVOLVED IN MHC CLASS-I RECOGNITION ARE DISULFIDE-LINKED HETERODIMERS OF CD94 AND NKG2 SUBUNITS

CD94 receptors expressed on NK cells have been implicated in the recog nition of certain HLA class I allotypes, We now demonstrate that CD94 glycoproteins form disulfide-bonded heterodimers with the NKG2A/B, NKG 2C, and NKG2E glycoproteins, NKG2A/B possesses two immunoreceptor tyro sine-based inhibition motif (ITIM) sequences in its cytoplasmic domain , which may be responsible for the inhibitory function of these recept ors, whereas other NKG2 proteins lack ITIMs and may potentially transm it positive signals, Structural heterogeneity in the NKG2 gene family and the formation of heterodimers with CD94 provides for the creation of a diverse NK cell repertoire.