EFFECT OF CONFORMATION OF N-ACYL CARNOSIN E AND CARCININE TOPOCHEMICAL ANALOGS ON THEIR ANTIOXIDANT PROPERTIES

Authors
ROZHKOVA EA OGREL SA GRIGOREV DN NEBOLSIN VE ZHELTUKHINA GA EVSTIGNEEVA RP
Citation
Ea. Rozhkova et al., EFFECT OF CONFORMATION OF N-ACYL CARNOSIN E AND CARCININE TOPOCHEMICAL ANALOGS ON THEIR ANTIOXIDANT PROPERTIES, Bioorganiceskaa himia, 22(10-11), 1996, pp. 838-845
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
22
Issue
10-11
Year of publication
1996
Pages
838 - 845
Database
ISI
SICI code
0132-3423(1996)22:10-11<838:EOCONC>2.0.ZU;2-6
Abstract
To elucidate the influence of the nature of N-acyl substituent on anti oxidant properties of carcinine analogs, the corresponding histamine d erivatives were synthesized. Antioxidant activity of the compounds pre pared was investigated in the Fe2+-ascorbate-dependent system of oxida tion of the linoleic acid micellar solution. Conformations of carnosin e, carcinine, and their analogs were calculated by the molecular mecha nics MM(+) method. The structural elements and conformations that are preferable for the appearance of antioxidant activity were found.