SEROTONINAMIDE OF ARACHIDONIC-ACID AS AN IRREVERSIBLE INHIBITOR OF SOYBEAN 15-LIPOXYGENASE

Authors
BEZUGLOV VV ARCHAKOV AV BOBROV MY KOGTEVA GS MANEVICH EM
Citation
Vv. Bezuglov et al., SEROTONINAMIDE OF ARACHIDONIC-ACID AS AN IRREVERSIBLE INHIBITOR OF SOYBEAN 15-LIPOXYGENASE, Bioorganiceskaa himia, 22(10-11), 1996, pp. 878-880
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
22
Issue
10-11
Year of publication
1996
Pages
878 - 880
Database
ISI
SICI code
0132-3423(1996)22:10-11<878:SOAAAI>2.0.ZU;2-J
Abstract
Acylation of 5-hydroxytryptamine (serotonin) and its analogues, trypta mine and 5-metoxytryptamine, with arachidonic acid is described. It ha s been shown that the substituted amides synthesized inhibit oxidation of arachidonic acid by soybean 15-lipoxygenase and are not the substr ates of this enzyme. It has been found that serotoninamide of arachido nic acid irreversibly inactivates lipoxygenase by a two-step mechanism .