MODIFIED TRIPHOSPHATES OF CARBOCYCLIC NUCLEOSIDE ANALOGS - SYNTHESIS,STABILITY TOWARDS ALKALINE-PHOSPHATASE AND SUBSTRATE PROPERTIES FOR SOME DNA-POLYMERASES

Authors
DYATKINA N SHIROKOVA E THEIL F ROBERTS SM KRAYEVSKY A
Citation
N. Dyatkina et al., MODIFIED TRIPHOSPHATES OF CARBOCYCLIC NUCLEOSIDE ANALOGS - SYNTHESIS,STABILITY TOWARDS ALKALINE-PHOSPHATASE AND SUBSTRATE PROPERTIES FOR SOME DNA-POLYMERASES, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2639-2642
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2639 - 2642
Database
ISI
SICI code
0960-894X(1996)6:22<2639:MTOCNA>2.0.ZU;2-X
Abstract
New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxyn ucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphat ase. Copyright (C) 1996 Elsevier Science Ltd