STEREOCHEMISTRY OF HYDROXYLATION DURING THE CONVERSION OF ALPHA-KETOISOCAPROATE TO BETA-HYDROXYISOVALERATE BY 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE

Authors
ADLINGTON RM BALDWIN JE CROUCH NP LEE MH MACKINNON CH PAUL DR
Citation
Rm. Adlington et al., STEREOCHEMISTRY OF HYDROXYLATION DURING THE CONVERSION OF ALPHA-KETOISOCAPROATE TO BETA-HYDROXYISOVALERATE BY 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2721-2724
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2721 - 2724
Database
ISI
SICI code
0960-894X(1996)6:22<2721:SOHDTC>2.0.ZU;2-7
Abstract
4-Hydroxyphenylpyruvate dioxygenase catalyzes the oxidative decarboxyl ation and hydroxylation of alpha-ketoisocaproate 1 to beta-hydroxyisov alerate 2 with retention of configuration during the hydroxylation ste p (Scheme 1). Copyright (C) 1996 Elsevier Science Ltd