SYNTHESIS AND BIOLOGICAL PROPERTIES OF PARTIALLY MODIFIED RETRO AND RETRO-INVERSO PSEUDO PEPTIDES OF ARG-GLY-ASP (RGD)

Authors
NISHIKAWA N KOMAZAWA H ORIKASA A YOSHIKANE M YAMAGUCHI J KOJIMA M ONO M ITOH I AZUMA I FUJII H MURATA J SAIKI I
Citation
N. Nishikawa et al., SYNTHESIS AND BIOLOGICAL PROPERTIES OF PARTIALLY MODIFIED RETRO AND RETRO-INVERSO PSEUDO PEPTIDES OF ARG-GLY-ASP (RGD), Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2725-2728
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2725 - 2728
Database
ISI
SICI code
0960-894X(1996)6:22<2725:SABPOP>2.0.ZU;2-I
Abstract
partially modified retro and retro-inverso peptide analogs of Arg-Gly- Asp (RGD) were synthesized and examined their inhibitory effects on ex perimental lung metastasis of murine melanoma and adenosine 5'-diphosp hate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation. Copyright (C) 1996 Elsevier Scie nce Ltd