NITROGEN AND SULFUR ANALOGS OF THE SECO-CO ALKYLATING AGENT - SYNTHESIS AND CYTOTOXICITY

Authors
TERCEL M DENNY WA WILSON WR
Citation
M. Tercel et al., NITROGEN AND SULFUR ANALOGS OF THE SECO-CO ALKYLATING AGENT - SYNTHESIS AND CYTOTOXICITY, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2735-2740
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2735 - 2740
Database
ISI
SICI code
0960-894X(1996)6:22<2735:NASAOT>2.0.ZU;2-#
Abstract
The first synthesis of seca-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In com parison with a phenol, an amino substituent confers reduced but signif icant cytotoxicity, even when mono- or dimethylated, while sulfur anal ogues are considerably less potent. Copyright (C) 1996 Elsevier Scienc e Ltd