STRUCTURAL COMPARISON OF ALKYLPOLYAMINE ANALOGS WITH POTENT IN-VITRO ANTITUMOR OR ANTIPARASITIC ACTIVITY

Authors
BELLEVUE FH BOAHBEDASON M WU RH WOSTER PM CASERO RA RATTENDI D LANE S BACCHI CJ
Citation
Fh. Bellevue et al., STRUCTURAL COMPARISON OF ALKYLPOLYAMINE ANALOGS WITH POTENT IN-VITRO ANTITUMOR OR ANTIPARASITIC ACTIVITY, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2765-2770
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2765 - 2770
Database
ISI
SICI code
0960-894X(1996)6:22<2765:SCOAAW>2.0.ZU;2-P
Abstract
A series of symmetrically or unsymmetrically alkyl-substituted polyami ne analogues were synthesized containing either a 3-3-3 or 3-7-3 polya mine backbone. These analogues were evaluated in vitro as antitumor ag ents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as ant itrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data sugg est that it is possible to specifically target tumor cells or parasiti c organisms with alkylpolyamine analogues based on structure. Copyrigh t (C) 1996 Elsevier Science Ltd