ENZYMATIC-SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2'-DEOXY-2'-FLUORO-RIBAVIRIN

Authors
SLATER MJ GOWRIE C FREEMAN GA SHORT SA
Citation
Mj. Slater et al., ENZYMATIC-SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2'-DEOXY-2'-FLUORO-RIBAVIRIN, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2787-2790
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
22
Year of publication
1996
Pages
2787 - 2790
Database
ISI
SICI code
0960-894X(1996)6:22<2787:EAAAO2>2.0.ZU;2-G
Abstract
2'-Deoxy-2'-fluoro-ribavirin has been efficiently synthesised from 2'- deoxy-2'-fluorouridine using nucleoside transferase as the key step, a nd evaluated for its antiviral properties in cell culture. An efficien t synthesis of chlorobenzoyl-2-deoxy-2-fluoro-beta-D-ribofuranose is a lso described. Copyright (C) 1996 Elsevier Science Ltd