STRUCTURE AND MECHANISM OF FORMATION OF A NEW ADDUCT FROM FORMALDEHYDE AND GUANOSINE

Authors
KENNEDY G SLAICH PK GOLDING BT WATSON WP
Citation
G. Kennedy et al., STRUCTURE AND MECHANISM OF FORMATION OF A NEW ADDUCT FROM FORMALDEHYDE AND GUANOSINE, Chemico-biological interactions, 102(2), 1996, pp. 93-100
Citations number
20
Categorie Soggetti
Toxicology,Biology,Chemistry,Biology
Journal title
Chemico-biological interactions → ACNP
ISSN journal
00092797
Volume
102
Issue
2
Year of publication
1996
Pages
93 - 100
Database
ISI
SICI code
0009-2797(1996)102:2<93:SAMOFO>2.0.ZU;2-I
Abstract
Reactions between formaldehyde and guanosine in the range pH 4-10 gave N-2-hydroxymethylguanosine 1, bis-N-2-guanosinylmethane 2 and 7,8-tet rahydro-sym-triazino[1,2-a]purin-10(3H)-one 3a. The latter is a new ad duct, the formation of which occurs in neutral solution, is favoured a t higher pH and can be rationalised by a sequence of condensations inv olving two molecules each of guanosine and formaldehyde.