THE INHIBITION OF ADENYLATE-CYCLASE IN EQUINE PLATELETS BY COLLAGEN AND BY PLATELET-ACTIVATING-FACTOR

Authors
FARNDALE RW NAPTHINE CS EVANS RJ HAYES LJ HEATH MF
Citation
Rw. Farndale et al., THE INHIBITION OF ADENYLATE-CYCLASE IN EQUINE PLATELETS BY COLLAGEN AND BY PLATELET-ACTIVATING-FACTOR, Platelets, 7(1-2), 1996, pp. 43-46
Citations number
22
Categorie Soggetti
Hematology,"Cell Biology
Journal title
Platelets → ACNP
ISSN journal
09537104
Volume
7
Issue
1-2
Year of publication
1996
Pages
43 - 46
Database
ISI
SICI code
0953-7104(1996)7:1-2<43:TIOAIE>2.0.ZU;2-V
Abstract
Equine platelet aggregation was stimulated by collagen fibres or plate let-activating factor. The action of both ligands was blocked by forsk olin or prostaglandin E(1), agents which are known to activate adenyla te cyclase. Equine platelet membranes were found to contain adenylate cyclase activity which was inhibited in dose-dependent fashion by both collagen and platelet-activating factor. Platelet-activating factor-i nduced inhibition was antagonised by WEB2086.