We address the possibility of bounding the spectral index n of primord
ial density fluctuations, using both the cosmic microwave background (
cmb) anisotropy, which probes scales 10(3) to 10(4) Mpc, and data on g
alaxies and clusters which probes scales 1 to 100 Mpc. Given n, suffic
iently accurate large scale data on the cmb anisotropy can determine t
he normalization of the primordial spectrum. Then the small scale data
are predicted within a given model of structure formation, which we h
ere lake as the MDM model determined by the Hubble parameter H-0 and t
he neutrino fraction Omega(v). Each piece of small scale data is reduc
ed to a value of sigma (R) (the linearly evolved rms density contrast
with top hat smoothing on scale R) which allows data on different scal
es to be readily compared. As a preliminary application, we normalize
the spectrum using the ten degree variance of the COBE data, and then
compare the prediction with a limited sample of low energy data, for v
arious values of n, Omega(v) and H-0. With H-0 fixed at 50 kms(-1) Mpc
(-1), the data constrain the spectral index to the range 0.7 less than
or similar to n less than or similar to 1.2. If gravitational waves c
ontribute to the cmb anisotropy with relative strength R = 6(1 - n) (a
s in some models of inflation), the lower limit on n is increased to a
bout 0.85. The uncertainty in H-0 widens this band by about 0.1 at eit
her end.