DIFFERENTIAL PRODUCTION OF INTERLEUKIN-6 AND ITS CLOSE RELATION TO LIVER METASTASIS IN CLONES FROM MURINE P815 MASTOCYTOMA

Authors
HOJO H SUN RJ ONO Y SHISHIDO T OBARA E YAMAZOE Y HASHIMOTO Y
Citation
H. Hojo et al., DIFFERENTIAL PRODUCTION OF INTERLEUKIN-6 AND ITS CLOSE RELATION TO LIVER METASTASIS IN CLONES FROM MURINE P815 MASTOCYTOMA, Cancer letters, 108(1), 1996, pp. 55-59
Citations number
22
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
108
Issue
1
Year of publication
1996
Pages
55 - 59
Database
ISI
SICI code
0304-3835(1996)108:1<55:DPOIAI>2.0.ZU;2-7
Abstract
Interleukin-6 (IL-6)-producing abilities of plastic-adherent and plast ic-non-adherent P815 clones were investigated in connection with the l iver metastasis. Most adherent clones produced IL-6 at high level (ove r 10 ng/10(5) cells per 48 h), and they coincided with highly liver-me tastatic clones. The remaining adherent and all the non-adherent clone s tested produced IL-6 at low level (under 1.5 ng/10(5) cells), and th ey coincided with the low or non-liver-metastatic clones. The IL-6 pro duction was greatly enhanced by IL-1 alpha, but not by IL-6, tumor nec rosis factor-alpha or interferon-gamma.