MANGOSTANOL, A PRENYL XANTHONE FROM GARCINIA-MANGOSTANA

During studies for identification of biologically active components fr om natural sources, a new polyoxygenated xanthone mangostanol was isol ated from the fruit hull of Garcinia mangostana, along with known xant hones, alpha-mangostin, gamma-mangostin, gartanin, 8-deoxygartnin, 5,9 -dihydroxy-2,2-dimethyl-8-methoxy-7-( ethylbut-2-enyl)-2H,6H-pyrano[3, 2-b]xanthen-6-one, garcinone E and mma-dimethylallyl)-1,7-dihydroxy-3- methoxyxanthone and epicatechin. Spectroscopic analysis mainly by 1D a nd 2D NMR spectroscopy, established the structure of mangostanol nyl)- 2H,6H-3,4-dihydropyrano[3,2-b]xanthen-6-one}. Mangostanol, and alpha- and gamma-mangostin show moderate inhibitory effects on cAMP phosphodi esterase. Copyright (C) 1996 Published by Elsevier Science Ltd