E. Barrettconnor et C. Frette, NIDDM, IMPAIRED GLUCOSE-TOLERANCE, AND PULMONARY-FUNCTION IN OLDER ADULTS - THE RANCHO-BERNARDO STUDY, Diabetes care, 19(12), 1996, pp. 1441-1444
Citations number
13
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
OBJECTIVE - To determine whether NIDDM or plasma glucose level in subj
ects without diabetes is associated with reduced pulmonary function in
525 men and 714 women, 51-95 years of age. RESEARCH DESIGN AND METHOD
S - The analysis was based on data from a community-based study, the R
ancho Bernardo Study. Between 1984 and 1987, 82% of community-dwelling
residents had an oral glucose tolerance test. Between 1988 and 1991,
80% had lung function assessed by spirometry (forced expiratory volume
in 1 s [FEV1] and forced vital capacity [FVC]). RESULTS - In analyses
adjusted for age, height, and cigarette smoking, pulmonary function n
as not associated with known or newly diagnosed NIDDM in men or women.
However, FEV1 and FVC were each independently reduced in men with dia
betes of 10 or more years duration. Fasting plasma glucose (FPG) level
s were correlated with FEV1 and FVC in men without diabetes. No associ
ations were found in women. CONCLUSIONS - The overall absence of an as
sociation of NIDDM with pulmonary function in these older adults may r
eflect survival bias and the small number of subjects with severe diab
etes or diabetes of prolonged duration. The apparent relation of FPG l
evels to FEV1 and FVC suggests that any effect of glycemia precedes di
abetes and contradicts any putative causal role for duration and sever
ity of glycemia, however. More epidemiological studies are needed to p
rovide further information about the relationship between NIDDM and lu
ng function.