TMDOTP5- - A SUBSTANCE FOR NMR TEMPERATURE-MEASUREMENTS IN-VIVO

The chemical shifts of P-31 and H-1 in thulium -tetraazacyclododecane- 1,4,7,10-tetrakis(methylene phosphonate) (ImDOTP(5-)) are approximatel y two orders of magnitude more sensitive to temperature than are water proton and F-19 shifts. In the physiologically relevant pH range, the P-31 and H-1 chemical shifts of TmDOTP5- are linear functions of temp erature between 25 and 47 degrees C. The results indicate that using T mDOTP5- can provide measurements of temperature in vivo that are signi ficantly more accurate than methods based on water and fluorocarbon ch emical shifts.