SYNTHESIS OF [12-H-3]-(+ -)-CALANOLIDE-A

Authors
REHDER KS HRISTOVAKAZMIERSKI MK KEPLER JA
Citation
Ks. Rehder et al., SYNTHESIS OF [12-H-3]-(+ -)-CALANOLIDE-A, Journal of labelled compounds & radiopharmaceuticals, 38(12), 1996, pp. 1077-1081
Citations number
6
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
12
Year of publication
1996
Pages
1077 - 1081
Database
ISI
SICI code
0362-4803(1996)38:12<1077:SO[->2.0.ZU;2-Y
Abstract
[12-H-3]-(+/-)-Calanolide A (9) was synthesized in five steps from rea dily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(III) chloride and sodium borotritide in meth anol gave 338 mu Ci of 9 with a specific activity of 63.0 mCi/mmol.