DIPEPTIDYL-PEPTIDASE-II IS RELATED TO LYSOSOMAL PRO-X CARBOXYPEPTIDASE

Authors
RAWLINGS ND BARRETT AJ
Citation
Nd. Rawlings et Aj. Barrett, DIPEPTIDYL-PEPTIDASE-II IS RELATED TO LYSOSOMAL PRO-X CARBOXYPEPTIDASE, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1298(1), 1996, pp. 1-3
Citations number
9
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Protein structure and molecular enzymology → ACNP
ISSN journal
01674838
Volume
1298
Issue
1
Year of publication
1996
Pages
1 - 3
Database
ISI
SICI code
0167-4838(1996)1298:1<1:DIRTLP>2.0.ZU;2-V
Abstract
The N-terminal amino-acid sequence of pig dipeptidyl-peptidase II (EC 3.4.14.2; DPP II) recently published (Huang, K., Takagaki, M., Kani, K . and Ohkubo, I. (1996) Biochim. Biophys. Acta 1290, 149-156) proves t hat the enzyme is homologous with lysosomal Pro-X carboxypeptidase (EC 3.4.16.2), and belongs to peptidase family S28 in dan SC. This is con sistent with a number of biochemical similarities between these two pr olyl bond-cleaving serine peptidases. DPP II is not related to granzym es, as was suggested by Huang et al.