CHROMATOGRAPHICALLY DERIVED HYDROPHOBICITY PARAMETERS IN QSAR ANALYSIS OF DIARYLSULPHONE ANALOGS

4-Amino-4'-substituted-diphenylsulphones have been synthesised and tes ted for antileprotic activity. The values of the parameters R(m) and l og k' have been estimated using reverse phase thin layer chromatograph y (RPTLC) and reverse phase high performance liquid chromatography (RP HPLC) respectively and correlated individually with calculated pi and molecular connectivity (chi) values in a typical Hansch analysis. Resu lts indicate that log k' is a better descriptor of lipophilicity than R(m) in the present homologous series of compounds. Molecular connecti vity index appears to be a poor descriptor of the lipophilic character istic of these compounds. Quantitative relationships between the vario us physicochemical parameters and biological activity have been analys ed using linear regression analysis. It has been found that electronic effect of a substituent is more contributive for inhibitory potency t han lipophilicity.