SYNTHESIS OF PYRAZOLINES, ISOXAZOLES AND CYANOPYRIDINES AS POTENTIAL ANTIMICROBIAL AGENTS

Authors
SHAH M PATEL P KORGAOKAR S PAREKH H
Citation
M. Shah et al., SYNTHESIS OF PYRAZOLINES, ISOXAZOLES AND CYANOPYRIDINES AS POTENTIAL ANTIMICROBIAL AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(12), 1996, pp. 1282-1286
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
35
Issue
12
Year of publication
1996
Pages
1282 - 1286
Database
ISI
SICI code
0376-4699(1996)35:12<1282:SOPIAC>2.0.ZU;2-D
Abstract
3,5-Dichloro-2-hydroxyacetophenone 1 on treatment with aromatic aldehy des yields 3,5-dichloro-2-hydroxy-omega-arylidine acetophenones 2a-j w hich on cyclisation with hydrazine hydrate, hydroxylamine hydrochlorid e and malononitrile furnishes the corresponding oro-2'-hydroxyphenyl)- 5-aryl-1-H/acetylpyrazolines 3a-j, 3a-j, (3',5'-dichloro-2'-hydroxyphe nyl)-5-arylisoxazoles 4a-j and 3-cyano-4-aryl-6-(3',5'-dichloro-2'-hyd roxyphenyl) pyridines 5a-j in appropriate solvents. Compounds 3'g, 4a, 4c, 5c and 5f exhibit highest antimicrobial activity against the vari ous strains of bacteria and fungi.