Hh. Yan et al., PREDICTION OF AFFINITIES OF PEPTIDES FOR CALMODULIN, Science in China. Series B, Chemistry, life sciences & earth sciences, 39(2), 1996, pp. 113-122
A simple method has been developed to predict the calmodulin-binding d
omains of peptides and the affinities of the peptides for calmodulin b
ased on a model for the calmodulin-binding domains of peptides propose
d in a previous paper and the literature data of calmodulin-binding pe
ptides. The effects of hydrophobicities, alpha-helix-forming tendencie
s, and basicities of peptides on their affinities for calmodulin were
studied. Model peptides were designed to examine the calmodulin-bindin
g domain model and the prediction method. The determined dissociation
constants of the complexes formed from the model peptides and calmodul
in are in good agreement with the predicted results.