EFFICACY AND SAFETY OF A COMBINATION OF I NDOMETHACIN AND GENTAMICIN AFTER CATARACT-SURGERY

Purpose The aim of the study was to compare 2 combinations of anti-inf lammatory drug and antibiotic in patients undergoing cataract surgery : 0.1 % indomethacin/gentamicin or 0.1 % dexamethasone/neomycin. Metho ds Two hundred and two patients undergoing extra-capsular cataract ext raction with posterior chamber lens implantation were included in a ra ndomized, double-blinded multicentric study comparing 2 parallel group s of treatment. Treatment was administered the day before surgery, the day of surgery and for the following 7 days. On the 8th post-operativ e day, the antibiotic was stopped and the anti-inflammatory treatment continued alone until the 30th post-operative day. Post-operative ocul ar inflammation was assessed clinically on the 1st, 7th, 15th and 30th post-operative days. The main evaluation criterion of treatment effic acy war the assessment of anterior chamber flare and cells. Results No statistically significant difference was observed between the 2 treat ment groups concerning post-operative inflammation. Both treatments we re well tolerated. Conclusion Eye drops combining 0.1 % indomethacin a nd gentamicin proved to be effective and well tolerated in preventing inflammation after cataract surgery.