EFFECT OF HIGH SUCROSE FEEDING ON FAT ACCUMULATION IN THE MALE WISTARRAT

High sucrose Intake is generally thought to be a risk factor for obesi ty and insulin resistance, We examined the effects of feeding sucrose on fat accumulation and insulin release in male rats, Six-week-old mal e Wister rats were maintained on a high sucrose diet for 4 or 12 weeks , Control rats were fed a diet based on starch, No significant differe nce in daily caloric intake or weight gain existed between the two die tary groups, There was no difference between the two dietary groups in the gain of abdominal subcutaneous fat (SC) at 4-week. In contrast, r ats fed the high sucrose diet had significantly more mesenteric fat (M ES) than controls (p<0.01), At 12 weeks, rats fed the high sucrose die t had significantly more SC and MES than controls (SC:p<0.05, MES:p<0. 01), Basal immunoreactive insulin (IRT) concentrations in the portal v ein (PV) of rats fed the high sucrose diet was significantly higher co mpared to those of controls (4 wk: p<0.05, 12 wk: p<0.05), No differen ce between the two dietary groups in basal WI concentrations ire the i nferior vena cava (IVC) existed at 4 weeks; whereas at 12 weeks, the b asal IRI concentrations in the IVC in rats fed the high sucrose diet w ere significantly higher than in controls (p<0.05), The mesenteric and subcutaneous fat accumulations were closely related to hyperinsulinem ia in the portal vein and inferior vena cava, respectively, Twelve wee ks of high sucrose feeding caused accumulation off abdominal adipose t issue with marked hyperinsulinemia and hyperlipidemia. Our study is th e first to demonstrate that abdominal fat induced by high sucrose inta ke in male rats is accompanied by an abnormal metabolic state similar to an insulin-resistant state.