EREMOMASTAX SPECIOSA - EFFECTS OF LEAF AQUEOUS EXTRACT ON ULCER FORMATION AND GASTRIC-SECRETION IN RATS

Authors
TAN PV NDITAFON NG YEWAH MP DIMO T AYAFOR FJ
Citation
Pv. Tan et al., EREMOMASTAX SPECIOSA - EFFECTS OF LEAF AQUEOUS EXTRACT ON ULCER FORMATION AND GASTRIC-SECRETION IN RATS, Journal of ethnopharmacology, 54(2-3), 1996, pp. 139-142
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Journal of ethnopharmacology → ACNP
ISSN journal
03788741
Volume
54
Issue
2-3
Year of publication
1996
Pages
139 - 142
Database
ISI
SICI code
0378-8741(1996)54:2-3<139:ES-EOL>2.0.ZU;2-U
Abstract
The anti-ulcerogenic potential of the aqueous extract of Eremomastax s peciosa leaves was investigated using two methods of ulcer induction: HCl/EtOH-induced ulceration and pylorus ligation. With both methods, t he extract inhibited gastric ulceration in a dose-related manner. The highest oral dose tested (190 mg/kg) completely inhibited gastric ulce ration and significantly reduced gastric acidity compared with the con trols. Incubation of gastric juice with the plant extract (190 mg/kg) significantly reduced the acidity of the incubated gastric juice compa red with the controls.