M. Zhu et al., APPLICATION OF RADIOLIGAND RECEPTOR-BINDING ASSAYS IN THE SEARCH FOR CNS ACTIVE PRINCIPLES FROM CHINESE MEDICINAL-PLANTS, Journal of ethnopharmacology, 54(2-3), 1996, pp. 153-164
Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastr
us angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarino
rum and C. bungei (Verbenaceae), Periploca callophylla and P. forresti
i (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria r
hynchophylla (Rubiaceae) were assessed for CNS activity against 18 rad
ioligand receptor binding assays. The receptors used were alpha 1-, al
pha 2- and beta-adrenoceptors, 5HT-1, 5HT-1A, 5HT-2, opiate, adenosine
-1, benzodiazepine, Ca+2 channel, sulphonylureas, dopamine-1, dopamine
-2, muscarinic, histamine-1, Na+/K+ ATPase, GABA(A) and GABA(B). The r
esults indicate that these ligand-receptor binding assays are useful f
or understanding the mode of action of herbal medicines and for bioass
ay guided fractionation of plant active ingredients.