This review of epidemiologic, clinical, and psychosocial/psychobehavio
ral data related to genital herpes simplex virus infection details the
increasing incidence of herpes simplex virus infection in the United
States and summarizes the data regarding the safety and efficacy of ch
ronic and acute antiviral therapy with acyclovir. It additionally esta
blishes the validity of psychosocial intervention as an adjunct to pha
rmacologic therapy for patients with recurrent genital herpes.