STUDIES ON ENDOTHELIN RECEPTORS IN THE ZONAE FASCICULATA RETICULARIS OF THE RAT ADRENAL-CORTEX - CONTRAST WITH THE ZONA GLOMERULOSA/

This study investigated the ET(A) and ET(B) receptor subtypes in rat a drenal cortex, The ET(A) antagonist, BQ-123, inhibited the zona glomer ulosa (zg), but not the inner zone (iz) response to ET-1, RES-701-1, t he ET(B) antagonist, abolished the it response to ET-1, but had less e ffect on the zg, [I-125]ET-1 binding studies revealed two receptor sub types in both zones, with ET(A) predominating in the zg, and ET(B) in the iz. These data suggest that the ET(A) subtype is functionally more important in the zg while the ET(B) receptor is the major subtype in the inner zones.