HUMAN HAIR FOLLICLE REGENERATION FOLLOWING AMPUTATION AND GRAFTING INTO THE NUDE-MOUSE

Citation
Cab. Jahoda et al., HUMAN HAIR FOLLICLE REGENERATION FOLLOWING AMPUTATION AND GRAFTING INTO THE NUDE-MOUSE, Journal of investigative dermatology, 107(6), 1996, pp. 804-807
Citations number
20
Categorie Soggetti
Dermatology & Venereal Diseases
ISSN journal
0022202X
Volume
107
Issue
6
Year of publication
1996
Pages
804 - 807
Database
ISI
SICI code
0022-202X(1996)107:6<804:HHFRFA>2.0.ZU;2-9
Abstract
In this study we investigated the capacity of the human hair follicle to regenerate a fiber-forming bulb after its amputation. We removed th e bases from terminal follicles from a variety of sites and transplant ed the follicles onto athymic mice, either still attached to a skin gr aft or as subcutaneous implants of individual follicles. External hair growth was observed on the skin grafts, and histology of the follicle s revealed restoration of dermal papillae and follicle bulb structures . This result suggests that the capacity of hair follicles to regenera te their lower structures after removal, which was first demonstrated on whisker follicles, may be a general phenomenon. It emphasizes the i mportance of specific cellular subpopulations within the follicle and the role of dermal-epidermal interactions in adult follicle activities .