EFFECTS OF DIETARY FATS AND CURCUMIN ON IGE-MEDIATED DEGRANULATION OFINTESTINAL MAST-CELLS IN BROWN-NORWAY RATS

Brown Norway rats were primed intraperitoneally with beta-lactoglobuli n for 3 wk to induce reaginic antibody, during which time they were fe d diets containing 10% each of coconut oil (CO), high oleic sail-lower oil, safflower oil (SO), or fish oil, then they were challenged for 3 h orally with the antigen. The dietary SO, compared to other dietary fats, resulted in lower circulatory release of rat chymaseII (RChyII), an indicator of degranulation of mucosal mast cells in the intestine, in response to the antigen. Addition of 0.5% curcumin to the CO or SO diet lowered the release. The SO diet, compared to CO diet, tended to increase the concentration of reaginic antibody, but the influence of curcumin addition was not prominent. These results indicate that diet ary ingredients differently influence the synthesis of immunoglobulin E and degranulation of mast cells.