DETERMINATION OF BETA-BLOCKER DRUGS IN PHARMACEUTICAL PREPARATIONS BYNON-SUPPRESSED ION CHROMATOGRAPHY

Authors
GHANEM R BELLO MA CALLEJON M GUIRAUM A
Citation
R. Ghanem et al., DETERMINATION OF BETA-BLOCKER DRUGS IN PHARMACEUTICAL PREPARATIONS BYNON-SUPPRESSED ION CHROMATOGRAPHY, Journal of pharmaceutical and biomedical analysis, 15(3), 1996, pp. 383-388
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
3
Year of publication
1996
Pages
383 - 388
Database
ISI
SICI code
0731-7085(1996)15:3<383:DOBDIP>2.0.ZU;2-Y
Abstract
A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non- suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous Solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg 1(-1). The method was suc cessfully applied to the determination of beta-blockers in several pha rmaceutical formulations.