STRUCTURE AND FUNCTION OF THE PROTEIN-TYROSINE PHOSPHATASES

Authors
FAUMAN EB SAPER MA
Citation
Eb. Fauman et Ma. Saper, STRUCTURE AND FUNCTION OF THE PROTEIN-TYROSINE PHOSPHATASES, Trends in biochemical sciences, 21(11), 1996, pp. 413-417
Citations number
48
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
21
Issue
11
Year of publication
1996
Pages
413 - 417
Database
ISI
SICI code
0968-0004(1996)21:11<413:SAFOTP>2.0.ZU;2-1
Abstract
The tyrosine and dual-specificity phosphatases are involved in signali ng, cell growth and differentiation, and the cell cycle. The enzymes s hare a common catalytic mechanism mediated by an active site cysteine, arginine and aspartic acid. Supplementary domains assist in targeting and substrate specificity.