3-PART INVENTIONS - INTRACELLULAR SIGNALING AND INDUCED PROXIMITY

Authors
CRABTREE GR SCHREIBER SL
Citation
Gr. Crabtree et Sl. Schreiber, 3-PART INVENTIONS - INTRACELLULAR SIGNALING AND INDUCED PROXIMITY, Trends in biochemical sciences, 21(11), 1996, pp. 418-422
Citations number
46
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
21
Issue
11
Year of publication
1996
Pages
418 - 422
Database
ISI
SICI code
0968-0004(1996)21:11<418:3I-ISA>2.0.ZU;2-3
Abstract
Everyone has had the experience of stoking a fire; putting the logs cl ose together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological res ponses. We discuss natural molecules that appear to have arisen to bri ng two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.