Knoevenagel type condensation of 4-unsubstituted isoxazolinones with k
etones or aldehydes followed by Michael addition of a nucleophile - hy
dride, cyanide, or phosphite- and exposure of the adduct to sodium nit
rite/aqueous acetic acid and ferrous sulfate gives variously functiona
lised alkynes. Copyright (C) 1996 Elsevier Science Ltd